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Lyme Disease in Dogs: Symptoms, Treatment & Prevention Guide

Dr. Jennifer Williams, DVM, DACVIM
Updated June 2026
9 min read

What is Lyme Disease?

Lyme disease is a tick-borne illness caused by the bacterium Borrelia burgdorferi. It is transmitted to dogs through the bite of infected black-legged ticks (deer ticks). Lyme disease is one of the most common tick-transmitted diseases in the world, with high prevalence in the Northeastern, Mid-Atlantic, and Upper Midwest United States.

How Dogs Get Lyme Disease

  • Black-legged tick (deer tick) must be attached for 24-48 hours
  • Tick must be infected with Borrelia burgdorferi
  • Not all tick bites transmit disease
  • Endemic areas: Northeast, Mid-Atlantic, Upper Midwest, Pacific Coast
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Symptoms

Early Signs (2-5 months after tick bite)

  • Fever (103-105°F)
  • Lethargy
  • Loss of appetite
  • Swollen lymph nodes

Joint Symptoms (Most Common)

  • Shifting leg lameness (limping moves from one leg to another)
  • Joint swelling and warmth
  • Stiffness (especially after rest)
  • Reluctance to move

Severe Complications

  • Lyme nephritis (kidney disease - most common in Labrador and Golden Retrievers)
  • Protein-losing nephropathy (protein in urine)
  • Kidney failure
  • Heart problems (rare)
  • Neurological signs (rare)

Asymptomatic Infection

  • 90-95% of infected dogs show NO symptoms
  • Positive test does not mean active disease
  • Decision to treat depends on symptoms, not just test results

Who Is at Risk?

  • Dogs in endemic areas (Northeast, Upper Midwest, Pacific Coast)
  • Hunting and hiking dogs (high tick exposure)
  • Dogs not on tick prevention
  • Labrador and Golden Retrievers (higher risk of kidney complications)
  • Young dogs (more likely to develop symptoms)

Diagnosis & Costs

Diagnostic Tests

  • 4Dx SNAP test (annual screening): $40-80 (tests for Lyme, Ehrlichia, Anaplasma, Heartworm)
  • Quant C6 test (confirms active infection): $100-200
  • CBC and chemistry: $150-300
  • Urinalysis (check for protein loss): $60-120
  • Joint fluid analysis (if lameness): $100-200

Total Diagnostic Cost: $100-600

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Treatment

Standard Protocol

  • Doxycycline (antibiotic): 4-week course, $30-80
  • Amoxicillin (alternative): 4-week course, $25-60
  • Anti-inflammatory (for joint pain): $20-50

Supportive Care

  • Rest during treatment (2-4 weeks)
  • Joint supplements (omega-3, glucosamine): $20-40/month
  • Pain medication (NSAIDs): $25-50

Kidney Disease Treatment (Lyme Nephritis)

  • Hospitalization: $500-1,500/day
  • IV fluids: $100-200/day
  • Medications (ACE inhibitors, special diet): $50-100/month
  • Long-term management: $100-300/month

Total Treatment Cost

  • Mild case: $50-$200
  • Moderate case: $200-$500
  • With kidney disease: $2,000-$8,000+

Prevention

Tick Prevention (Monthly)

  • Oral: NexGard, Bravecto, Simparica ($15-30/month)
  • Topical: Frontline, Advantix ($15-25/month)
  • Collars: Seresto ($50-70 for 8 months)

Vaccination

  • Lyme vaccine for dogs: $25-45 per dose
  • Initial series: Two doses, 3-4 weeks apart
  • Annual booster for at-risk dogs
  • Recommended for: Dogs in endemic areas, hunting dogs, dogs with high tick exposure

Tick Management

  • Check for ticks daily during tick season
  • Remove ticks promptly (within 24 hours prevents transmission)
  • Keep grass trimmed and remove leaf litter
  • Avoid tick-infested areas during peak season
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Prognosis

With Treatment

  • Joint symptoms: Usually resolve within 3-5 days of starting antibiotics
  • Full recovery: 4 weeks of antibiotics typically clears infection
  • Reinfection possible: Antibodies do not provide long-term immunity
  • Kidney disease: Prognosis guarded, lifelong management needed

Long-Term Effects

  • Most dogs recover fully from joint symptoms
  • Kidney damage may be permanent
  • Chronic arthritis possible in untreated cases

Related: heartworm-disease, fleas-ticks, leptospirosis

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